Biogerontology

, Volume 4, Issue 1, pp 15–18

Establishment of the mimetic aging effect in mice caused by D-galactose

Article

DOI: 10.1023/A:1022417102206

Cite this article as:
Ho, SC., Liu, JH. & Wu, RY. Biogerontology (2003) 4: 15. doi:10.1023/A:1022417102206

Abstract

We successfully established an oxidant damageof mimetic aging model using mice induced byD-galactose, and the mimetic aging model isrelative to free radical and the accumulationof waste substances in metabolism. The animalswere divided into 3 groups: (1)phosphate-buffered saline (PBS); (2) 1%D-galactose; (3) 5% D-galactose bysubcutaneous injection every day. After 45days, mice treated with D-galactose showed asignificant increase in the malondialdehyde(MDA), total antioxidant status (TAS) and adecrease in superoxide dismutase (SOD) in the blood comparedwith the PBS group. In the brain, theD-galactose treated mice exhibited a higherlevel MDA and a lower level SOD activity.In the liver, only the 5% D-galactose groupindicated a significant increase in MDA. By reference to theoxidative biomarkers in blood, brain and liver,we have confirmed the reliability of themimetic aging model.

D-dalactosefree radicalmalondialdehydemimetic aging modelsuperoxide dismutasetotal antioxidant status

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  1. 1.Traditional Chinese Medicine Division, Development Center for BiotechnologyTaipeiTaiwan, R.O.C.