Molecular Biology

, Volume 37, Issue 1, pp 37–48

Immunomodulatory Proteins of Orthopoxviruses

  • S. N. Shchelkunov

DOI: 10.1023/A:1022324511384

Cite this article as:
Shchelkunov, S.N. Molecular Biology (2003) 37: 37. doi:10.1023/A:1022324511384


The review considers recent data on the structural–functional organization of the genome of orthopoxviruses pathogenic for humans, including the variola, monkeypox, cowpox, and vaccinia viruses. Emphasis was placed on the structure of molecular virulence factors that suppress the inflammatory reactions, immune response, and interferon effects induced by virus infection.

orthopoxvirusesvariola virusmonkeypox viruscowpox virusvaccinia virusimmunomodulationgenomecomputer analysis

Copyright information

© MAIK “Nauka/Interperiodica” 2003

Authors and Affiliations

  • S. N. Shchelkunov
    • 1
  1. 1.Institute of Molecular Biology, State Research Center of Virology and Biotechnology“Vector” Ministry of Health of the Russian FederationKoltsovoRussia