Heart Failure Reviews

, Volume 8, Issue 1, pp 47–54

Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies

Authors

  • David Alonso
    • Department of Integrative Biology and PharmacologyUniversity of Texas-Houston
    • Department of Integrative Biology and PharmacologyUniversity of Texas-Houston
Article

DOI: 10.1023/A:1022194921040

Cite this article as:
Alonso, D. & Radomski, M.W. Heart Fail Rev (2003) 8: 47. doi:10.1023/A:1022194921040

Abstract

Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.

nitric oxide platelet function myocardial infarction reperfusion

Copyright information

© Kluwer Academic Publishers 2003