Heart Failure Reviews

, Volume 8, Issue 1, pp 107–115

The Nitric Oxide-Endothelin-1 Connection


DOI: 10.1023/A:1022155206928

Cite this article as:
Alonso, D. & Radomski, M.W. Heart Fail Rev (2003) 8: 107. doi:10.1023/A:1022155206928


Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.

nitric oxideendothelinvascular tonecardiovascular systemreceptor antagonistheart failure

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  1. 1.Department of Integrative Biology and PharmacologyUniversity of Texas-HoustonUSA