The Nitric Oxide-Endothelin-1 Connection
- Cite this article as:
- Alonso, D. & Radomski, M.W. Heart Fail Rev (2003) 8: 107. doi:10.1023/A:1022155206928
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Nitric oxide (NO) and endothelin-1 (ET-1) are endothelium-derived mediators that play important roles in vascular homeostasis. This review is focused on the role and reciprocal interactions between NO and ET-1 in health and diseases associated with endothelium dysfunction. We will also discuss the clinical significance of NO donors and drugs that antagonize ET receptors.