Kulisevsky, J., Pujol, J., Junque, C., Deus, J., Balanzo, J., and Capdevila, A. 1993. MRI pallidal hyperintensity and brain atrophy in cirrhotic patients: two different MRI patterns of clinical deterioration? Neurology 43:2570–2573.
Inoue, E., Hori, S., Narumi, Y., Fujita, M., Kuriyama, K., Kadota, T., and Kuroda, C.H. 1991. Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MRI images. Radiology 179:551–555.
Hauser, R. A., Zefiewicz, T., and Olanow, C. W. 1994. Manganese overload may cause the clinical and magnetic resonance imaging abnormalities of chronic liver disease. Movement Disorders 9(Suppl. 1): 118.
Nelson, K., Golnick, J., Korn, T., and Angle, C. 1993. Manganese encephalopathy: utility of early magnetic resonance imaging. Br. J. Ind. Med. 50:510–513
Mirowitz, S. A., and Westrich, T. J. 1992. Basal ganglia signal intensity alterations: reversal after discontinuation of parenteral manganese administration. Radiology 185:535–536.
Newland, M. C., Ceckler, T. L., Kordower, J. H., and Weiss, B. 1989. Visualizing manganese in the primate basal ganglia with magnetic resonance imaging. Exp. Neurol. 106:251–258.
Pomier Layrargues, G., Spahr, L., and Butterworth, R. F. 1995. Increased manganese concentrations in pallidum of cirrhotic patients. Lancet 345:735.
Krieger, D., Krieger, S., Jansen, O., Gass, P., Theilmann, L., and Lichtnecker, H. 1995. Manganese and chronic hepatic encephalopathy. Lancet 346:270–274.
Norenberg, M. D., Neary, J. T., Bender, A. S., and Dombro, R. S. 1992. Hepatic encephalopathy: a disorder in glial-neuronal communication. Prog. Brain Res. 94:261–269.
Norenberg, M. D. 1996. Astrocytic-ammonia interactions in hepatic encephalopathy. Semin. Liver Dis. 16:245–253.
Adams, R. D., and Foley, J. M. 1953. The neurological disorder associated with liver disease. Pages 198–237, in Merritt, H. H., and Hare, C. C. (eds.), Metabolic and Toxic Diseases of the Nervous System, Williams and Wilkins, Baltimore.
Norenberg, M. D. 1981. The astrocyte in liver disease. Adv. Cell. Neurobiol. 2:303.
Pentschew, A., Ebner, F. F., and Kovatch, R. M. 1963. Experimental manganese encephalopathy in monkeys: a preliminary report. J. Neuropathol. Exp. Neurol. 22:488–499.
Tholey, G., Ledig, M., Mandel, P., Sargentini, L., Frivold, A. H., Leroy, M., Grippo, A. A., and Wedler, F. C. 1987. Concentrations of physiologically important metal ions in glial cells cultured from chick cerebral cortex. Neurochem. Res. 12:45–50.
Wedler, F. C., Ley, B. W., and Grippo, A. A. 1989. Manganese(II) dynamics and distribution in glial cells cultured from chick cerebral cortex. Neurochem. Res. 14:1129–1135.
Wedler, F. C., Denman, R. B., and Roby, W. G. 1982. Glutamine synthetase from ovine brain is a manganese(II) enzyme. Biochemistry 21:6389–6396.
Schousboe, A., Drejer, J., and Hertz, L. 1988. Uptake and release of glutamate and glutamine in neurons and astrocytes in primary cultures. Pages 21–39, in Kvamme, E. (ed.), Glutamine and Glutamate in Mammals, Vol. II, CRC Press, Boca Raton.
Moroni, F., Lombardi, G., Monetti, G., and Cortesini, C. 1983. The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. J. Neurochem. 40:850–854.
Tossman, U., Delin, A., Eriksson, S., and Ungerstedt, U. 1987. Brain cortical amino acids measured by intracerebral dialysis in portacaval shunted rats. Neurochem. Res. 12:265–269.
De Knegt, R. J., Schalm, S. W., van der Rijt, C. C. D., Fekkes, D., Dalm, E., and Hekking-Weyma, I. 1994. Extracellular brain glutamate during acute liver failure and during acute hyperammonemia simulating acute liver failure: an experimental study based on in vivo brain dialysis. J. Hepatol. 20:17–26.
Bender, A. S., and Norenberg, M. D. 1996. Effects of ammonia on L-glutamate uptake in cultured astrocytes. Neurochem. Res. 21:567–573.
Huo, Z., Neary, J. T., Petito, C. K., and Norenberg, M. D. 1995. The glutamate transporter GLT-1 is downregulated in hyperammonemia and acute liver failure. Soc. Neurosci. Absts. 21:1081.
Norenberg, M. D., Huo, Z., Neary, J. T., and Roig-Cantesano, A. 1997. The glial glutamate transporter in hyperammonemia and hepatic encephalopathy: relation to energy metabolism and glutamatergic neurotransmission. Glia. In press.
Hazell, A. S., and Norenberg, M. D. 1995. Manganese decreases glutamate uptake in cultured astrocytes. Soc. Neurosci. Abst. 21: 1984.
Booher, J., and Sensenbrenner, M. 1972. Growth and cultivation of dissociated neurons and glial cells from embryonic chick, rat, and human brain in flask cultures. Neurobiol. 2:97–105.
Drejer, J., Larsson, O. M., and Schousboe, A. 1982. Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions. Exp. Brain Res. 47: 259–269.
Bender, A. S., Woodbury, D. M., and White, H. S. 1989. β-DL-Methylene-aspartate, an inhibitor of aspartate aminotransferase, potently inhibits L-glutamate uptake into astrocytes. Neurochem. Res. 14:641–646.
Drejer, J., Larsson, O. M., and Schousboe, A. 1983. Characterization of uptake and release processes for D-and L-aspartate in primary cultures of astrocytes and cerebellar granule cells. Neurochem. Res. 8:231–243.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:263–275.
Ohashi, M., Amano, S., Hazama, F., and Handa, J. 1993. Hypoxic effects on glutamate uptake in cultured glial cells. Acta Pathol. Japon. 43, 154–159.
Lowry, O. H., and Passonneau, J. V. 1972. A Flexible System of Enzymatic Analysis, Academic Press, New York.
Wroblewski, F., and LaDue, J. S. 1955. Lactic dehydrogenase activity in blood. Proc. Soc. Exp. Biol. Med. 90:210–213.
Aschner, M., Gannon, M., and Kimelberg, H. K. 1992. Manganese uptake and efflux in cultured rat astrocytes. J. Neurochem. 58: 730–735.
Aschner, M., Eberle, N. B., Miller, K., and Kimelberg, H. K. 1990. Interactions of methylmercury with rat primary astrocyte cultures: inhibition of rubidium and glutamate uptake and induction of swelling. Brain Res. 530:245–250.
Defazio, G., Soleo, L., Zefferino, R., and Livrea, P. 1996. Manganese toxicity in serumless dissociated mesencephalic and striatal primary culture. Brain Res. Bulletin 40:257–262.
Sakurai, H., Nishida, M., Yoshimura, T., Takada, J., and Koyama, M. 1985. Partition of divalent and total manganese in organs and subcellular organelles of MnCl2-treated rats studied by ESR and neutron activation analysis. Biochim. Biophys. Acta 841:208–214.
Rao, V. L. R., and Murthy, Ch. R. K. 1991. Hyperammonemic alterations in the uptake and release of glutamate and aspartate by rat cerebellar preparations. Neurosci. Lett. 130:49–52.
Gregorios, J. B., Mozes, L. W., Norenberg, L. O. B., and Norenberg, M. D. 1986. Morphologic effects of ammonia on primary astrocyte cultures: I. Light microscopic studies. J. Neuropath. Exp. Neurol. 44:397–403.
Gregorios, J. B., Mozes, L. W., and Norenberg, M. D. 1986. Morphologic effects of ammonia on primary astrocyte cultures: II. Electron microscopic studies. J. Neuropath. Exp. Neurol. 44: 404–414.
Wagner, R., Rosenberg, M., and Estensen, R. 1971. Endocytosis of Chang liver cells. Quantitation by sucrose-3H uptake and inhibition by cytochalasin B. J. Cell Biol. 50:804–817.
Silverstein, S. C., Steinman, R. M., and Cohn, Z. A. 1977. Endocytosis. Ann. Rev. Biochem. 46:669–722.
Sun, A. Y., Yang, W. L., and Kim, H. D. 1993. Free radical and lipid peroxidation in manganese-induced neuronal cell injury. Ann. N.Y. Acad. Sci. 679:358–363.
Desole, M. S., Esposito, G., Migheli, R., Fresu, L., Sircana, S., Miele, M., De Natale, G., and Miele, E. 1995. Allopurinol protects against manganese-induced oxidative stress in the striatum and in the brainstem of the rat. Neurosci. Lett. 192:73–76.
Hexum, T. D., and Fried, R. 1979. Effects of superoxide radicals on transport (Na + K) adenosine triphosphatase and protection by superoxide dismutase. Neurochem. Res. 4:73–82.
Piani, D., Frei, K., Pfister, H.-W., and Fontana, A. 1993. Glutamate uptake by astrocytes is inhibited by reactive oxygen intermediates but not by other macrophage-derived molecules including cytokines, leukotrienes or platelet-activating factor. J. Neuroimmunol. 48:99–104.
Volterra, A., Trotti, D., Tromba, C., Floridi, S., and Racagni, G. 1994. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J. Neurosci. 14:2924–2932.