Digestive Diseases and Sciences

, Volume 48, Issue 2, pp 395–398

Changing Presentation of Adult Celiac Disease

  • Winson Lo
  • Kevin Sano
  • Ben Lebwohl
  • Beverly Diamond
  • Peter H.R. Green
Article

DOI: 10.1023/A:1021956200382

Cite this article as:
Lo, W., Sano, K., Lebwohl, B. et al. Dig Dis Sci (2003) 48: 395. doi:10.1023/A:1021956200382

Abstract

The mode of presentation of celiac disease in the United States is not known. We investigated the demographic and clinical features of 227 patients with biopsy-proven celiac disease and determined if there had been changes over time. The patients had been entered into a database; those seen prior to 1990 were retrospectively entered while those seen subsequently were prospectively entered. A “symptomatic” presentation described the “classical” presentation of celiac disease with prominent gastrointestinal symptoms: diarrhea and weight loss. Females were younger and had a longer duration of symptoms compared to males. The modes of presentation were symptomatic (62%), anemia or reduced bone density (15%), screening first-degree relatives (13%), and incidental diagnosis at endoscopy (8%). We compared those diagnosed before and after 1993 (when serologic testing was first used), and noted a reduction in those presenting with diarrhea, 73% vs 43% (P = 0.0001) and a reduction in the duration of symptoms, from 9.0 ± 1.1 years to 4.4 ± 0.6 years (P < 0001). In conclusion, the percentage of celiac disease patients presenting with diarrhea has decreased, probably related to the more widespread use of serologic testing for celiac disease.

celiac diseasepresentationepidemiologydiarrhea

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Winson Lo
    • 1
  • Kevin Sano
    • 1
  • Ben Lebwohl
    • 1
  • Beverly Diamond
    • 1
  • Peter H.R. Green
    • 1
  1. 1.Department of MedicineColumbia University College of Physicians and Surgeons, New YorkNew YorkUSA