Digestive Diseases and Sciences

, Volume 48, Issue 1, pp 179–186

Effects of Orthotopic Liver Transplantation on Vasoactive Systems and Renal Function in Patients with Advanced Liver Cirrhosis

  • Concepción Cassinello
  • Enrique Moreno
  • Adolfo Gozalo
  • Blanca Ortuño
  • Beatriz Cuenca
  • José Antonio Solís-Herruzo
Article

DOI: 10.1023/A:1021763221337

Cite this article as:
Cassinello, C., Moreno, E., Gozalo, A. et al. Dig Dis Sci (2003) 48: 179. doi:10.1023/A:1021763221337
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Abstract

The effects of Orthotopic liver transplantation (OLT) on renal function and major vasoactive factors was assessed in end-stage cirrhotic patients. Renal function, mean arterial pressure, and plasma vasoactive hormones were measured In 22 cirrhotic patients with refractory ascites before and after OLT. Before OLT, mean arterial pressure, glomerular filtration rate, free water clearance, and fractional sodium excretion serum sodium levels were decreased. In addition, serum creatinine and plasma levels of vasoactive factors were increased. Ten of these patients fulfilled criteria of hepatorenal syndrome (HRS). Nine to 12 months after transplantation, renal function had improved and plasma levels of vasoactive factors had decreased significantly in all patients, including those with HRS. However, glomerular filtration rate remained subnormal and plasma endothelin-1 levels and plasma renin activity remained increased in most of them. In conclusion, OLT improves renal function in patients with end-stage liver cirrhosis, including those with HRS. However, renal function remains subnormal in most of these patients.

hepatorenal syndrome renal function orthotopic liver transplantation vasoactive systems endothelin-1 

Copyright information

© Plenum Publishing Corporation 2003

Authors and Affiliations

  • Concepción Cassinello
    • 1
    • 2
  • Enrique Moreno
    • 3
    • 2
  • Adolfo Gozalo
    • 4
    • 2
  • Blanca Ortuño
    • 5
    • 2
  • Beatriz Cuenca
    • 1
    • 2
  • José Antonio Solís-Herruzo
    • 1
    • 2
  1. 1.Department of GastroenterologyHospital Universitario “12 de Octubre.”Madrid
  2. 2.Hospital Universitario “Miguel Servet”ZaragozaSpain
  3. 3.Department of SurgeryHospital Universitario “12 de Octubre.”Madrid
  4. 4.Department of BiochemistryHospital Universitario “12 de Octubre.”Madrid
  5. 5.Department of Nuclear MedicineHospital Universitario “12 de Octubre.”Madrid

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