, Volume 8, Issue 1, pp 5–9

Multi-functional gene ASY/Nogo/RTN-X/RTN4: Apoptosis, tumor suppression, and inhibition of neuronal regeneration


DOI: 10.1023/A:1021639016300

Cite this article as:
Watari, A. & Yutsudo, M. Apoptosis (2003) 8: 5. doi:10.1023/A:1021639016300


ASY, also designated Nogo, RTN-X, or RTN4, is a reticulon family protein containing two transmembrane domains and a C-terminal double lysine endoplasmic reticulum (ER) retrieval motif. Three protein variants are synthesized from the cognate mRNAs produced by alternative splicing, and are expressed in almost all tissues, localizing predominantly in the ER. The ASY protein induces apoptosis in various cancer cells when overexpressed, whereas normal cells are relatively resistant to ASY-dependent apoptosis. Furthermore, transcription of this gene is suppressed in certain types of cancers, suggesting that ASY may act to suppress tumor development. Although the physiological function of this protein has not been well defined, Nogo-A protein, the large variant of ASY, has been shown to inhibit neuronal regeneration in the central nervous system. Therefore, the products of this gene may be multi-functional, regulating apoptosis, tumor development, and neuronal regeneration.

apoptosisASYneuronal regenerationNogoRTN-Xtumor suppression

Copyright information

© Kluwer Academic Publishers 2003

Authors and Affiliations

  1. 1.Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan