Intracellular drug delivery using poly(d,l-lactide- co-glycolide) nano- particles derivatized with a peptide from a transcriptional activator protein of HIV-1
Cite this article as: Nam, Y.S., Park, J.Y., Han, S. et al. Biotechnology Letters (2002) 24: 2093. doi:10.1023/A:1021373731787 Abstract
co-glycolide) (PLGA) nanoparticles were derivatized with Tat 49−57 peptide, which is the protein transduction domain from the transcriptional activator Tat protein of human immunodeficiency virus type-1 (HIV-1). The Tat 49−57 peptide-modified PLGA nanoparticles, with a mean diameter of ca. 238 nm, was effectively adsorbed on to the membrane of HaCaT cells and delivered into the nuclei without cytotoxicity. biodegradable polymer conjugates nanoparticles protein transduction domain (PTD) Tat peptide References
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