Biotechnology Letters

, Volume 24, Issue 24, pp 2093–2098

Intracellular drug delivery using poly(d,l-lactide-co-glycolide) nano- particles derivatized with a peptide from a transcriptional activator protein of HIV-1

Authors

  • Yoon Sung Nam
    • Amore Pacific R&D Center
  • Ju Young Park
    • Amore Pacific R&D Center
  • Sang-Hoon Han
    • Amore Pacific R&D Center
  • Ih-Seop Chang
    • Amore Pacific R&D Center
Article

DOI: 10.1023/A:1021373731787

Cite this article as:
Nam, Y.S., Park, J.Y., Han, S. et al. Biotechnology Letters (2002) 24: 2093. doi:10.1023/A:1021373731787

Abstract

Biodegradable poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles were derivatized with Tat49−57 peptide, which is the protein transduction domain from the transcriptional activator Tat protein of human immunodeficiency virus type-1 (HIV-1). The Tat49−57 peptide-modified PLGA nanoparticles, with a mean diameter of ca. 238 nm, was effectively adsorbed on to the membrane of HaCaT cells and delivered into the nuclei without cytotoxicity.

biodegradable polymerconjugatesnanoparticlesprotein transduction domain (PTD)Tat peptide

Copyright information

© Kluwer Academic Publishers 2002