Cancer and Metastasis Reviews

, Volume 21, Issue 3, pp 281–289

New Concepts in Selenium Chemoprevention

  • Clement Ip
  • Yan Dong
  • Howard E. Ganther
Article

DOI: 10.1023/A:1021263027659

Cite this article as:
Ip, C., Dong, Y. & Ganther, H.E. Cancer Metastasis Rev (2002) 21: 281. doi:10.1023/A:1021263027659

Abstract

This article highlights some recent advances in selenium cancer chemoprevention research. It has been well documented that the chemical transformation of selenium to a monomethylated metabolite is an important step in achieving cancer prevention. Studies with the rat mammary carcinogenesis model suggested that methylselenocysteine (MSC), a good precursor for generating methylselenol endogenously, is able to block clonal expansion of premalignant lesions in the mammary gland. This finding supports the notion that selenium intervenes at an early stage of carcinogenesis. In addition to decreasing cell proliferation of the transformed colonies in vivo, MSC also enhances apoptosis. These same cellular responses are replicated with human premalignant breast cells grown in culture. cDNA microarray analysis indicated that selenium affects a multitude of molecular targets. Based on this information, a number of signaling pathways are proposed that could potentially provide insight into how selenium might block cell cycle progression and induce cell death.

methylselenocysteine selenium metabolism cancer chemoprevention molecular biomarkers cDNA microarray analysis 

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Clement Ip
    • 1
  • Yan Dong
    • 1
  • Howard E. Ganther
    • 2
  1. 1.Department of Experimental PathologyRoswell Park Cancer InstituteBuffaloUSA
  2. 2.Department of Nutritional SciencesUniversity of WisconsinMadisonUSA