Cancer and Metastasis Reviews

, Volume 21, Issue 3, pp 257–264

Carotenoids in Cancer Chemoprevention

Authors

  • Hoyoku Nishino
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Michiaki Murakoshi
    • Department of BiochemistryKyoto Prefectural University of Medicine
    • Research & Development HeadquartersLion Corporation
  • Tsunehiro Ii
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Manabu Takemura
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Masashi Kuchide
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Motohiro Kanazawa
    • Department of UrologyKyoto Prefectural University of Medicine
  • Xiao Yang Mou
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Saeri Wada
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Mitsuharu Masuda
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Yasuhito Ohsaka
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Shingo Yogosawa
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Yoshiko Satomi
    • Department of BiochemistryKyoto Prefectural University of Medicine
  • Kenji Jinno
    • Internal MedicineShikoku Cancer Center
Article

DOI: 10.1023/A:1021206826750

Cite this article as:
Nishino, H., Murakoshi, M., Ii, T. et al. Cancer Metastasis Rev (2002) 21: 257. doi:10.1023/A:1021206826750

Abstract

Various natural carotenoids, besides β-carotene, were proven to have anticarcinogenic activity, and some of them showed more potent activity than β-carotene. Thus, these carotenoids (α-carotene, lutein, zeaxanthin, lycopene, rbeta β-cryptoxanthin, fucoxanthin, astaxanthin, capsanthin, crocetin and phytoene), as well as β-carotene, may be useful for cancer prevention. In the case of phytoene, the concept of 'bio-chemoprevention', which means biotechnology-assisted method for cancer chemoprevention, may be applicable. In fact, establishment of mammalian cells producing phytoene was succeeded by the introduction of crtB gene, which encodes phytoene synthase, and these cells were proven to acquire the resistance against carcinogenesis. Antioxidative phytoene-containing animal foods may be classified as a novel type of functional food, which has the preventive activity against carcinogenesis, as well as the ability to reduce the accumulation of oxidative damages, which are hazardous for human health.

natural carotenoidsmulticarotenoidscancer chemopreventionbio-chemopreventionfunctional foods

Copyright information

© Kluwer Academic Publishers 2002