A comparative study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules
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Phase pure hydroxyapatite (HA) and a 0.8 wt % silicon substituted hydroxyapatite (SiHA) were prepared by aqueous precipitation methods. Both HA and SiHA were processed into granules 0.5–1.0 mm in diameter and sintered at 1200 °C for 2 h. The sintered granules underwent full structural characterization, prior to implantation into the femoral condyle of New Zealand White rabbits for a period of 23 days. The results show that both the HA and SiHA granules were well accepted by the host tissue, with no presence of any inflammatory cells. New bone formation was observed directly on the surfaces and in the spaces between both HA and SiHA granular implants. The quantitative histomorphometry results indicate that the percentage of bone ingrowth for SiHA (37.5%±5.9) was significantly greater than that for phase pure HA (22.0%±6.5), in addition the percentage of bone/implant coverage was significantly greater for SiHA (59.8%±7.3) compared to HA (47.1%±3.6). These findings indicate that the early in vivo bioactivity of hydroxyapatite was significantly improved with the incorporation of silicate ions into the HA structure, making SiHA an attractive alternative to conventional HA materials for use as bone substitute ceramics.
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- A comparative study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules
Journal of Materials Science: Materials in Medicine
Volume 13, Issue 12 , pp 1199-1206
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- 1. Department of Materials Science and Metallurgy, University of Cambridge, New Museums Site, Pembroke Street, Cambridge, CB2 3QZ, UK
- 2. IRC Biomedical Materials, Queen Mary University of London, Mile End Road, London, E1 4NS, UK
- 3. IRC Biomedical Materials, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2QG, UK