Neurochemical Research

, Volume 27, Issue 10, pp 957–980

mRNA Stability and the Control of Gene Expression: Implications for Human Disease

Authors

  • Elysia M. Hollams
    • Laboratory for Cancer Medicine and University Department of MedicineWestern Australian Institute for Medical Research and University of Western Australia
  • Keith M. Giles
    • Laboratory for Cancer Medicine and University Department of MedicineWestern Australian Institute for Medical Research and University of Western Australia
  • Andrew M. Thomson
    • Laboratory for Cancer Medicine and University Department of MedicineWestern Australian Institute for Medical Research and University of Western Australia
  • Peter J. Leedman
    • Laboratory for Cancer Medicine and University Department of MedicineWestern Australian Institute for Medical Research and University of Western Australia
Article

DOI: 10.1023/A:1020992418511

Cite this article as:
Hollams, E.M., Giles, K.M., Thomson, A.M. et al. Neurochem Res (2002) 27: 957. doi:10.1023/A:1020992418511

Abstract

Regulation of gene expression is essential for the homeostasis of an organism, playing a pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple studies over the last two decades have demonstrated that the modulation of mRNA stability plays an important role in regulating gene expression. The stability of a given mRNA transcript is determined by the presence of sequences within an mRNA known as cis-elements, which can be bound by trans-acting RNA-binding proteins to inhibit or enhance mRNA decay. These cis-trans interactions are subject to a control by a wide variety of factors including hypoxia, hormones, and cytokines. In this review, we describe mRNA biosynthesis and degradation, and detail the cis-elements and RNA-binding proteins known to affect mRNA turnover. We present recent examples in which dysregulation of mRNA stability has been associated with human diseases including cancer, inflammatory disease, and Alzheimer's disease.

mRNA stabilitymRNA decaycis-elementsRNA-binding proteinsdiseasecancer

Copyright information

© Plenum Publishing Corporation 2002