, Volume 67, Issue 10, pp 1089-1098

Pyridoxal 5"-Phosphate as a Catalytic and Conformational Cofactor of Muscle Glycogen Phosphorylase b

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Abstract

This review summarizes data on structure of muscle glycogen phosphorylase b and the role of the cofactor pyridoxal 5"-phosphate in catalysis and stabilizing the native conformation of the enzyme. Specific attention is paid to the stabilizing role of pyridoxal 5"-phosphate upon denaturation of phosphorylase b. Stability of holoenzyme, apoenzyme, and enzyme reduced by sodium borohydride is compared.