Biomedical Microdevices

, Volume 4, Issue 4, pp 301–308

Polymer-Based Packaging Platform for Hybrid Microfluidic Systems

  • P. Krulevitch
  • W. Benett
  • J. Hamilton
  • M. Maghribi
  • K. Rose
Article

DOI: 10.1023/A:1020958323891

Cite this article as:
Krulevitch, P., Benett, W., Hamilton, J. et al. Biomedical Microdevices (2002) 4: 301. doi:10.1023/A:1020958323891

Abstract

A polymer-based packaging platform for creating hybrid microfluidic systems is presented. Polydimethylsiloxane (PDMS) is cast into an acrylic mold frame with suspended elements that are removed after curing to form chip cavities, inlet and outlet ports, microchannels, and reservoirs. The packaging approach enables the integration of off-the-shelf components such as pumps and valves with glass microfluidic devices, electronic chips, sample reservoirs, and flow channels. A particle pre-concentration module with a glass capture chip and integrated micropump is shown as an example. A pneumatically driven microfluidic pumping module is also shown. Custom microfluidic interconnects for interfacing to micro-scale fluidic systems are presented. The connectors are capable of withstanding more than 1000 psi and allow microdevices to be rapidly connected to macroscopic devices and systems, without the use of tools.

packaging microfluidic systems polydimethylsiloxane (PDMS) hybrid integration polymer molding 

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • P. Krulevitch
    • 1
  • W. Benett
    • 1
  • J. Hamilton
    • 1
  • M. Maghribi
    • 1
  • K. Rose
    • 1
  1. 1.Lawrence Livermore National LaboratoryCenter for Micro TechnologyLivermoreUSA

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