Neurochemical Research

, Volume 27, Issue 10, pp 1123–1131

Theoretical Consideration of Amplification Strategies

  • Chad A. Shaw

DOI: 10.1023/A:1020917223962

Cite this article as:
Shaw, C.A. Neurochem Res (2002) 27: 1123. doi:10.1023/A:1020917223962


Experimentalists would like to perform large-scale expression analysis on samples drawn from small cell populations and even single cells. Amplification of the source material is required to assay such small samples under all existing array technologies. In this report we consider the very different theoretical properties of linear and PCR-based amplification. A suggestion is made concerning a hybrid amplification strategy incorporating the advantages offered by both approaches.

Amplificationexpression arraysstochastic modelingbranching process

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Chad A. Shaw
    • 1
  1. 1.Department of Molecular and Human GeneticsBaylor College of MedicineHouston