Heart Failure Reviews

, Volume 7, Issue 4, pp 385–389

Nitric Oxide in Heart Failure: Friend or Foe


  • Bodh I. Jugdutt

DOI: 10.1023/A:1020767731450

Cite this article as:
Jugdutt, B.I. Heart Fail Rev (2002) 7: 385. doi:10.1023/A:1020767731450


Nitric oxide (NO) is a controversial molecule. It is either beneficial or deleterious. As with NO donors, one reason for this duality is related to the dose. Small doses are highly beneficial, maintaining blood flow in vessels and blood pressure, and protecting against foreign invaders. In high doses, it results in hypotension, forms peroxynitrite which is cytotoxic, and contributes to heart failure.

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Copyright information

© Kluwer Academic Publishers 2002