Journal of Protein Chemistry

, Volume 18, Issue 4, pp 447–465

Structure–Function Analysis of the ADAM Family of Disintegrin-Like and Metalloproteinase-Containing Proteins (Review)

  • Anne L. Stone
  • Michaela Kroeger
  • Qing Xiang Amy Sang
Article

DOI: 10.1023/A:1020692710029

Cite this article as:
Stone, A.L., Kroeger, M. & Sang, Q.X.A. J Protein Chem (1999) 18: 447. doi:10.1023/A:1020692710029

Abstract

The ADAMs belong to adisintegrin-like and metalloproteinase-containing protein family that are zinc-dependent metalloproteinases. These proteins share all or some of the following domain structure: a signal peptide, a propeptide, a metalloproteinase, a disintegrin, a cysteine-rich, and an epidermal growth factor (EGF)-like domains, a transmembrane region, and a cytoplasmic tail. ADAMs are widely distributed in many organs, tissues, and cells, such as brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone, and muscle. These proteins are capable of four potential functions: proteolysis, adhesion, fusion, and intracellular signaling. Because the number of ADAM genes has grown rapidly and the biological functions of most members are unclear, this review analyzes the protein structures and functions, their activation and processing, their known and potential activities, and their evolutionary relationships. A sequence alignment of human ADAMs is compiled and their homology and physical data are calculated. The conceivable functions of ADAMs in reproduction, development, and diseases are also discussed.

Metzincin metalloproteinase/disintegrin/cysteine-rich (MDC) computational sequence analysis physical data calculation homology comparison 

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Anne L. Stone
    • 1
    • 2
  • Michaela Kroeger
    • 1
    • 2
  • Qing Xiang Amy Sang
    • 1
  1. 1.Department of Chemistry and Institute of Molecular BiophysicsFlorida State UniversityTallahassee
  2. 2.The first two authors contributed equally to this workUSA

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