Journal of Clinical Immunology

, Volume 22, Issue 6, pp 375–380

Primary Immunodeficiency in Iran: First Report of the National Registry of PID in Children and Adults

  • Asghar Aghamohammadi
  • Mosafa Moein
  • Abolhasan Farhoudi
  • Zahra Pourpak
  • Nima Rezaei
  • Kamran Abolmaali
  • Masoud Movahedi
  • Mohammad Gharagozlou
  • Bahram Mir Saeid Ghazi
  • Maryam Mahmoudi
  • Davoud Mansouri
  • Saba Arshi
  • Naser Javaher Trash
  • Hedayatallah Akbari
  • Roya Sherkat
  • Reza Farid Hosayni
  • Ahmad Hashemzadeh
  • Iraj Mohammadzadeh
  • Reza Amin
  • Sara Kashef
  • Abdalvahab Alborzi
  • Abdallah Karimi
  • Hosaynali Khazaei
Article

DOI: 10.1023/A:1020660416865

Cite this article as:
Aghamohammadi, A., Moein, M., Farhoudi, A. et al. J Clin Immunol (2002) 22: 375. doi:10.1023/A:1020660416865

Abstract

Epidemiological studies have shown wide geographical and racial variation in the prevalence and patterns of immunodeficiency disorders. To determine the frequency of primary immunodeficiencies (PID) in Iran, the Iranian Primary Immunodeficiency Registry (IPIDR) was organized in 1999. We extracted the patient’s data, by using a uniform questionnaire from their hospital records. The diagnosis of patients was based on WHO criteria. By now, 440 patients with PID, who were observed during a period of 20 years, have been registered in our registry. Among these patients, the following frequencies were found: predominantly antibody deficiency in 45.9% of patients (n = 202), phagocytic disorders in 29.09% (n = 128), T-cell disorders in 24.31% (n = 107), and complement deficiencies in 0.68% (n = 3). Common variable immunodeficiency was the most frequent disorder (n = 98), followed by chronic granulomatous disease (n = 86), ataxia telangiectasia (n = 48), x-linked agammaglobulinemia (n = 45), selective IgA deficiency (n = 42), combined immunodeficiency (n = 15), and severe combined immunodeficiency (n = 14). This study revealed that antibody deficiencies is the most frequently diagnosed primary immunodeficiency disorder in our patients, which is similar to that observed in other registries. A comparative study shows some differences between our results and other registries.

Primary immunodeficiencyNational registryIran

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Asghar Aghamohammadi
    • 1
  • Mosafa Moein
    • 1
  • Abolhasan Farhoudi
    • 1
  • Zahra Pourpak
    • 1
  • Nima Rezaei
    • 1
  • Kamran Abolmaali
    • 1
  • Masoud Movahedi
    • 1
  • Mohammad Gharagozlou
    • 1
  • Bahram Mir Saeid Ghazi
    • 1
  • Maryam Mahmoudi
    • 1
  • Davoud Mansouri
    • 2
  • Saba Arshi
    • 3
  • Naser Javaher Trash
    • 3
  • Hedayatallah Akbari
    • 4
  • Roya Sherkat
    • 4
  • Reza Farid Hosayni
    • 5
  • Ahmad Hashemzadeh
    • 5
  • Iraj Mohammadzadeh
    • 6
  • Reza Amin
    • 7
  • Sara Kashef
    • 7
  • Abdalvahab Alborzi
    • 8
  • Abdallah Karimi
    • 8
  • Hosaynali Khazaei
    • 9
  1. 1.Department of Clinical Pediatric Immunology, Children’s Medical Center. TehranUniversity of Medical Sciences, TehranIran
  2. 2.Department of Infectious Disease, Masih Daneshvari Hospital. BeheshtiUniversity of Medical Sciences, TehranIran
  3. 3.Department of Immunology and Allergy, Al-rasoul HospitalUniversity of Medical Sciences, Tehran, IranIran
  4. 4.Department of Clinical Pediatric Immunology, Al-Zahara Hospital. IsfahanUniversity of Medical Sciences, IsfahanIran
  5. 5.Department of Immunology and Allergy, MashhadUniversity of Medical Sciences, MashhadIran
  6. 6.Department of Clinical Pediatric Immunology, BabolUniversity of Medical Sciences, BabolIran
  7. 7.Department of Immunology and Allergy, Nemazi Hospital, ShirazUniversity of Medical Sciences, ShirazIran
  8. 8.Department of Pediatric Infectious Diseases, Nemazi hospital, ShirazUniversity of Medical Sciences, ShirazIran
  9. 9.Department of Immunology, ZahedanUniversity of Medical Sciences, ZahedanIran