, Volume 21, Issue 1-3, pp 47-54

Metal-Oxo Species in P450 Enzymes and Biomimetic Models. Oxo-Hydroxo Tautomerism with Water-Soluble Metalloporphyrins

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Abstract

Oxygenation reactions (hydroxylation, epoxidation, N- or S-oxide formation, etc.) catalyzed by cytochrome P450 enzymes and related biomimetic models involve an electrophilic oxidative species as the active species, namely a high-valent metal-oxo intermediate. Among the different methods to study the oxygenation reactions mediated by high-valent metal-oxo porphyrin complexes, the recent discovery of oxo-hydroxo tautomerism provides a useful tool to investigate the mechanism of O-atom transfer reactions in aqueous media.