, Volume 19, Issue 1, pp 1-11

Interleukin-18 and Interleukin-1β: Two Cytokine Substrates for ICE (Caspase-1)

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Abstract

This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1β and the novel cytokine IL-18, which was formerly called IFNγ-inducing factor (IGIF). The “classical” pathways of cytokine processing are described, as well as the importance of alternative cleavage enzymes. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.