Journal of Clinical Immunology

, Volume 19, Issue 1, pp 1–11

Interleukin-18 and Interleukin-1β: Two Cytokine Substrates for ICE (Caspase-1)

  • Giamila Fantuzzi
  • Charles A. Dinarello

DOI: 10.1023/A:1020506300324

Cite this article as:
Fantuzzi, G. & Dinarello, C.A. J Clin Immunol (1999) 19: 1. doi:10.1023/A:1020506300324


This special article deals with the role of processing enzymes in the generation of bioactive cytokines, particularly IL-1β and the novel cytokine IL-18, which was formerly called IFNγ-inducing factor (IGIF). The “classical” pathways of cytokine processing are described, as well as the importance of alternative cleavage enzymes. The topic of this review also concerns the biology of IL-18. The regulation of IL-18 production, the IL-18 receptor complex, and the biological effects of this novel cytokine are described.

Cytokines processing enzymes proteinase-3 interleukin-18 interleukin-1 caspases 

Copyright information

© Plenum Publishing Corporation 1999

Authors and Affiliations

  • Giamila Fantuzzi
    • 1
  • Charles A. Dinarello
    • 1
  1. 1.Department of Medicine, Division of Infectious DiseasesUniversity of Colorado Health Sciences CenterDenver
  2. 2.University of Colorado Health Sciences CenterDenver

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