Digestive Diseases and Sciences

, Volume 47, Issue 11, pp 2625–2634

Efficacy of Probiotic Use in Acute Diarrhea in Children: A Meta-Analysis

  • Jeannie S. Huang
  • Athos Bousvaros
  • John W. Lee
  • Angela Diaz
  • Emily J. Davidson
Article

DOI: 10.1023/A:1020501202369

Cite this article as:
Huang, J.S., Bousvaros, A., Lee, J.W. et al. Dig Dis Sci (2002) 47: 2625. doi:10.1023/A:1020501202369

Abstract

Our objective was to determine the efficacy of probiotic use in reducing the duration of increased stool output in children with acute diarrheal illness. Eligible studies were limited to trials of probiotic therapy in otherwise healthy children <5 years old with acute-onset diarrhea. The main outcome variable was difference in diarrhea duration between treatment and control groups. Our meta-analysis of 18 eligible studies suggests that coadministration of probiotics with standard rehydration therapy reduces the duration of acute diarrhea by ∼1 day [random-effects pooled estimate = −0.8 days (−1.1, −0.6), P < 0.001]. Differences in treatment effect between studies was assessed by calculating the Q statistic (Q = 204.1, P < 0.001). In subsequent analyses limited to studies of hospitalized children, to double-blinded trials, and to studies evaluating lactobacilli, the pooled estimates were similar (−0.6 to −1.2 days, P < 0.001). In conclusion, bacterial probiotic therapy shortens the duration of acute diarrheal illness in children by approximately one day.

probioticsdiarrheachildrenmeta-analysis

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • Jeannie S. Huang
    • 1
    • 2
  • Athos Bousvaros
    • 1
    • 2
  • John W. Lee
    • 2
  • Angela Diaz
    • 2
    • 3
  • Emily J. Davidson
    • 1
    • 2
  1. 1.Children's HospitalBostonUSA
  2. 2.Harvard School of Public HealthBostonUSA
  3. 3.Mount Sinai School of MedicineNew YorkUSA