Molecular Biology Reports

, Volume 29, Issue 1, pp 51–55

Dynamic Stability of Signal Transduction Networks Depending on Downstream and Upstream Specificity of Protein Kinases

  • Bernd Binder
  • Reinhart Heinrich

DOI: 10.1023/A:1020302318189

Cite this article as:
Binder, B. & Heinrich, R. Mol Biol Rep (2002) 29: 51. doi:10.1023/A:1020302318189


Mathematical methods are used for explaining the structural design of signal transduction networks, e.g. MAP kinase cascades, which control cell proliferation, differentation or apoptosis. Taking into account protein kinases and phosphatases the interrelation between the topology of signaling networks and the stability of their ground state are analysed. It is shown that the stability is closely related to the system's dimension and to the number of cycles within the network. Systems with a higher number of kinases and/or cycles tend to be more unstable. In contrast to that increasing phosphatase activity stabilises the ground state.

signaling networkdynamical stabilityground stateMAP kinasesspecificitydigraphscycles

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Bernd Binder
    • 1
  • Reinhart Heinrich
    • 1
  1. 1.Theoretical Biophysics, Institute of Biology, Math.-Nat. Dept. IHumboldt University BerlinBerlin(Germany)