Key Role of Succinate Dehydrogenase in Insulin-Induced Inactivation of Protein Tyrosine Phosphatases
- Cite this article as:
- Pomytkin, I.A. & Kolesova, O.E. Bulletin of Experimental Biology and Medicine (2002) 133: 568. doi:10.1023/A:1020229724717
We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H2O2that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H2O2and inactivation of liver protein tyrosine phosphatases.