Bulletin of Experimental Biology and Medicine

, Volume 133, Issue 6, pp 568–570

Key Role of Succinate Dehydrogenase in Insulin-Induced Inactivation of Protein Tyrosine Phosphatases


DOI: 10.1023/A:1020229724717

Cite this article as:
Pomytkin, I.A. & Kolesova, O.E. Bulletin of Experimental Biology and Medicine (2002) 133: 568. doi:10.1023/A:1020229724717


We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H2O2that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H2O2and inactivation of liver protein tyrosine phosphatases.

succinate dehydrogenase protein tyrosine phosphatase insulin hydrogen peroxide succinate 

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  1. 1.Department of General Pathology and PathophysiologyRussian Medical Academy of Postgraduate Education, Russian Ministry of HealthMoscow