Neurochemical Research

, Volume 27, Issue 7, pp 583–592

Gangliosides with O-Acetylated Sialic Acids in Tumors of Neuroectodermal Origin


  • Guido Kohla
    • Biochemisches InstitutChristian-Albrechts-Universität zu Kiel
  • Eggert Stockfleth
    • Universitätshautklinik Charité Schumannstraße 20
  • Roland Schauer
    • Biochemisches InstitutChristian-Albrechts-Universität zu Kiel

DOI: 10.1023/A:1020211714104

Cite this article as:
Kohla, G., Stockfleth, E. & Schauer, R. Neurochem Res (2002) 27: 583. doi:10.1023/A:1020211714104


Gangliosides, carrying an O-acetylated sialic acid in their carbohydrate moiety, are often found in growing and developing tissues, especially of neuro-ectodermal origin. The most prominent one is 9-O-Ac-GD3, which is considered as an oncofetal marker in animal and human tumors like neuronal tumors, melanoma, basalioma or breast cancer, as well as in psoriatic lesions. Also other gangliosides like GD2 or GT3 were found to be O-acetylated in their terminal sialic acid. In this review we are summarising the occurrence of such gangliosides in normal and transformed tissues and delineate a more general theory that O-acetylated sialic acids in gangliosides are a universal marker for growing cells and tissues.

GangliosideneuroectodermalO-acetylationsialic acidtumor

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© Plenum Publishing Corporation 2002