, Volume 3, Issue 5, pp 307–316

Accumulation of insoluble protein and aging

  • Anund Hallén

DOI: 10.1023/A:1020155502734

Cite this article as:
Hallén, A. Biogerontology (2002) 3: 307. doi:10.1023/A:1020155502734


It is proposed that biological aging mainly depends on a deleterious accumulation of insoluble inert protein that has escaped physiological proteolytic degradation. Intracellularly, a three-dimensional network of polypeptide chains may exclude macromolecular structures and organelles from part of the cytosolic water. In this way vital intracellular transport mechanisms may be obstructed, providing a rationale to several observations linked to aging.

agingexclusioninsoluble proteinpolypeptide net work

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • Anund Hallén
    • 1
  1. 1.Department of Medical Biochemistry and MicrobiologyUniversity of Uppsala, Biomedical CenterUppsalaSweden