Scalp Topography of the Spontaneous K-Complex and of Delta-Waves in Human Sleep
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Objective: Together with spindles, K-complexes are well known hallmarks of stage 2 sleep (S2). However, little is known about their topographical distribution in comparison to delta-waves and to K-complexes superimposed by spindles. Patients and methods: In this study, the topographical distribution of spontaneous K-complexes and delta-waves in S2 and delta-waves in stage 4 sleep (S4) in 10 healthy young adults (aged 20 to 35 years, 7 female) was investigated. K-complexes with and without spindles in S2, delta-waves with and without spindles in S2, and delta-waves in S4 distributed all over the night were visually selected. EEG power maps and statistical parametric maps were calculated. Results: Absolute delta power of S2 K-complexes appeared to be significantly higher than of S2 delta-waves and delta power of S4 delta-waves was higher than of S2 delta-waves. In K-complexes and delta-waves, power was found to be highest over medio-frontal regions in the delta frequency band (0.5 - 4.0 Hz) with a second maximum occipitally in delta-waves, no matter whether superimposed by a spindle or not. Conclusion: K-complexes and delta-waves in S2 differ in topographical distribution. Even though in S2 delta-waves have less power, they have a similar topographical distribution in S2 and S4, supporting the hypothesis that delta-waves in S2 further develop towards delta-waves in slow wave sleep. The delta frequency components of K-complexes and delta-waves are unaffected by spindles.
- Achermann, P. and Borbély, A.A. Low-frequency (<1Hz) oscillations in the human sleep EEG. Neuroscience, 1997, 81: 213–222.
- Amzica, F. and Steriade, M. The K-complex: its slow (<1-Hz) rhythmicity and relation to delta waves. Neurology, 1997, 49: 952–959.
- Amzica, F. and Steriade, M. Cellular substrates and laminar profile of sleep K-complex. Neuroscience, 1998a, 82: 671–686.
- Amzica, F. and Steriade, M. Electrophysiological correlates of sleep delta waves. Electroencephalogr. Clin. Neurophysiol., 1998b, 107: 69–83.
- Anderer, P., Klösch, G., Gruber, G., Trenker, E., Pascual-Marqui, R.D., Zeitlhofer, J., Barbanoj, M.J., Rappelsberger, P. and Saletu, B. Low-resolution brain electromagnetic tomography (LORETA) revealed simultaneously active frontal and parietal sleep spindle sources in the human cortex. Neuroscience, 2001, 103: 581–592.
- Anderer, P., Saletu, B., Kinsperger, K. and Semlitsch H. Topographic brain mapping of EEG in neuropsychopharmacology. Part I. Methodological aspects. Methods Find. Exp. Clin. Pharmacol., 1987, 9: 371–384.
- Bankman, I.N., Sigillito, V.G., Wise, R.A. and Smith, P.L. Feature-based detection of the K-complex wave in the human electroencephalogram using neural networks. IEEE Trans. Biomed. Eng., 1992, 39: 1305–1310.
- Bastien, C. and Campbell, K. The evoked K-complex: All-or-none phenomenon? Sleep, 1992, 15: 236–245.
- Bastien, C. and Campbell, K. Effects of rate of tone-pip stimulation on the evoked K-complex. J. Sleep Res., 1994, 3: 65–72.
- Beier, K.M. and Kubicki, S. Kortikale Verteilung zweier d-Frequenzen im langsamen Schlaf. Z.EEGEMG, 1987, 18: 47–51.
- Campbell, K., Bell, I. and Bastien, C. Evoked potential measures of information processing during natural sleep. In: R.J. Broughton and R.D. Oglivie (Eds.), Sleep, arousal, and performance. Birkhäuser, Boston, 1992: 88–116.
- Colrain, I.M., Webster, K.E. and Hirst, G. The N550 component of the evoked K-complex: A modality non-specific response? J. Sleep Res., 1999, 8: 273–280.
- Cote, K.A., de Lugt, D.R., Langley, S.D. and Campbell, K.B. Scalp topography of the auditory evoked K-complex in stage 2 and slow wave sleep. J. Sleep Res., 1999, 8: 263–272.
- da Rosa, A.C., Kemp, B., Paiva, T., Lopes da Silva, F.H. and Kamphuisen, H.A.C. A model-based detector of vertex waves and K complexes in sleep electroencephalogram. Electroencephalogr. Clin. Neurophysiol., 1991, 78: 71–78.
- da Rosa, A.C. and Paiva, T. Automatic detection of K-complexes: validation in normals and dythymic patients. Sleep, 1993, 16: 239–248.
- Davis, H., Davis, P.A., Loomis, A.L., Harvey, E.N. and Hobart, G. Electrical reactions of the human brain to auditory stimulation during sleep. J. Neurophysiol., 1939, 2: 500–514.
- Gibbs, F.A. and Gibbs, E.L. Atlas of electroencephalography, Vol. 1. Addison-Wesley, Reading, MA, 1950.
- Harsh, J., Voss, U., Hull, J., Schrepfer, S. and Badia, P. ERP and behavioural changes during the wake/sleep transition. Psychophysiology, 1994, 31: 244–252.
- Herrmann, W.M., on behalf of the International Pharmaco-EEG group (IPEG).Recommendations for EEG and evoked potential mapping. Neuropsychobiology, 1989, 22: 170–176.
- Jankel, W.R. and Niedermeyer, E. Sleep spindles. J. Clin. Neurophysiol., 1985, 2: 1–35.
- Jobert, M., Poiseau, E., Jahnig, P., Schulz, H. and Kubicki, S. Topographical analysis of sleep spindle activity. Neuropsychobiology, 1992, 26: 210–217.
- Kubicki, S. and Herrmann, W.M. The future of computer-assisted investigation of the polysomnogram: sleep microstructure. J. Clin. Neurphysiol., 1996, 13: 285–294.
- Loomis, A.L., Harvey, N. and Hobart III, G.A. Distribution of disturbance patterns in the human electroencephalogram, with special reference to sleep. J. Neurophysiol., 1939, 1: 413–430.
- Maquet, P. and Phillips, C. Functional brain imaging of human sleep. J. Sleep Res., 1998, 7 (Suppl 1): 42–47.
- McCormick, L., Nielsen, T., Nicolas, A., Ptito, M. and Montplaisir, J. Topographical distribution of spindles and K-complexes in normal subjects. Sleep, 1997, 20: 939–941.
- Niiyama, Y., Fushimi, M., Sekine, A. and Hishikawa, Y. K-complex evoked in NREM sleep is accompanied by a slow negative potential related to cognitive process. Electroencephalogr. Clin. Neurophysiol., 1995, 95: 27–33.
- Niiyama, Y., Satoh, N., Kutsuzawa, O. and Hishikawa, Y. Electrophysiological evidence suggesting that sensory stimuli of unknown origin induce spontaneous K-complexes. Electroencephalogr. Clin. Neurophysiol., 1996, 98: 394–400.
- Picton, T.W., Lins, O.G. and Scherg, M. The recording and analysis of event-related potentials. In: F. Boller and J. Grafman (Eds.), Handbook of Neuropsychology. Amsterdam, Elsevier Science, 1995, 10: 1–73.
- Rechtschaffen, A. and Kales, A. A manual of standardized terminology technique and scoring system for sleep stages of human subject. Brain Information Service, University of California, 1968.
- Roth, M., Shaw, J. and Green, J. The form, voltage distribution and physiological significance of the K-complex. EEG Clin. Neurophysiol., 1956, 8: 385–402.
- Sallinen, M., Kaartinen, J. and Lyytinen, H. Is the appearance of mismatch negativity during stage 2 sleep related to the elicitation of K-complex? Electroencephalogr. Clin. Neurophysiol., 1994, 91: 140–148.
- Steriade, M., Contreras, D., Curro Dossi, R. and Nunez, A. The slow (<1 Hz) oscillation in reticular thalamic and thalamocortical neurons: scenario of sleep rhythm generation in interacting thalamic and neocortical networks. J. Neuroscience, 1993a, 13: 3284–3299.
- Steriade, M., Contreras, D. and Amzica, F. Synchronized sleep oscillations and their paroxysmal developments. Trends Neurosci., 1994, 17: 199–210.
- Steriade, M., Nunez, A. and Amzica, F. Intracellular analysis of relations between the slow (<1 Hz) neocortical oscillation and other sleep rhythms of the electroencephalogram. J. Neurosci., 1993 b, 13: 3266–83.
- Walter, W.G. The living brain. London: Duckworth, 1953.
- Wauquier, A., Aloe, L. and Declerck, A. K-complexes: are they signs of arousal or sleep protective? J. Sleep Res., 1995, 4: 138–143.
- Werth, E., Achermann, P., Dijk, D.J. and Borbély, A.A. Spindle frequency activity in the sleep EEG: individual differences and topographic distribution. Electroencephalogr. Clin. Neurophysiol., 1997, 103: 535–542.
- Zeitlhofer, J., Anderer, P., Obergottsberger, S., Schimicek, P., Lurger, S., Marschnigg, E., Saletu, B. and Deecke, L. Topographic mapping of EEG during sleep. Brain Topography, 1993, 6: 123–129.
- Zeitlhofer, J., Gruber, G., Anderer, P., Asenbaum, S., Schimicek, P. and Saletu, B. Topographic distribution of sleep spindles in young healthy subjects. J. Sleep Res., 1997, 6: 149–155.
- Scalp Topography of the Spontaneous K-Complex and of Delta-Waves in Human Sleep
Volume 15, Issue 1 , pp 43-49
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Sleep spindle
- Stage 2 sleep
- Stage 4 sleep
- Author Affiliations
- 1. Department of Neurology,, University of Vienna,, Austria
- 2. Department of Clinical Neurophysiology,, University of Goettingen,, Germany
- 3. Department of Psychiatry,, University of Vienna,, Austria
- 4. Department of Neurology,, University of Vienna,, Austria