Bulletin of Experimental Biology and Medicine

, Volume 133, Issue 5, pp 442–443

Glutathione-Dependent System of Antioxidant Defense in the Placenta in Preterm Delivery

  • V. M. Prokopenko
  • G. K. Partsalis
  • N. G. Pavlova
  • S. O. Burmistrov
  • A. V. Arutyunyan
Article

DOI: 10.1023/A:1019845217485

Cite this article as:
Prokopenko, V.M., Partsalis, G.K., Pavlova, N.G. et al. Bulletin of Experimental Biology and Medicine (2002) 133: 442. doi:10.1023/A:1019845217485

Abstract

Components of the antioxidant defense system in placental tissues were studied in women with normal pregnancy and full-term delivery and women with spontaneous abortions at 28-36 weeks. In women with spontaneous abortions glutathione peroxidase activity in placental tissues increased and the content of SH compounds decreased, which led to exhaustion of the antioxidant defense system. Glutathione-S-transferase activity also decreased, which attests to impaired detoxifying function of the placenta.

glutathione peroxidaseglutathione reductaseglutathione transferaseplacentapreterm delivery

Copyright information

© Plenum Publishing Corporation 2002

Authors and Affiliations

  • V. M. Prokopenko
    • 1
  • G. K. Partsalis
    • 1
  • N. G. Pavlova
    • 1
  • S. O. Burmistrov
    • 1
  • A. V. Arutyunyan
    • 1
  1. 1.D. O. Ott Institute of Obstetrics and GynecologyRussian Academy of Medical SciencesSt. Petersburg