Article

Molecular Breeding

, Volume 9, Issue 3, pp 149-158

First online:

Practical considerations for pharmaceutical antibody production in different crop systems

  • Eva StogerAffiliated withFraunhofer Department for Molecular Biotechnology, IUCT, Grafschaft
  • , Markus SackAffiliated withInstitute for Biology I, RWTH Aachen
  • , Yolande PerrinAffiliated withUniv. de Compiegne
  • , Carmen VaqueroAffiliated withInstitute for Biology I, RWTH Aachen
  • , Esperanza TorresAffiliated withSainsbury Laboratory
  • , Richard M. TwymanAffiliated withFraunhofer Department for Molecular Biotechnology, IUCT, Grafschaft
  • , Paul ChristouAffiliated withFraunhofer Department for Molecular Biotechnology, IUCT, Grafschaft
  • , Rainer FischerAffiliated withFraunhofer Department for Molecular Biotechnology, IUCT, Grafschaft

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Abstract

The potential of plant cells to produce functional recombinantantibodies has been demonstrated in a number of different plant systems. Wepresent a comparative study of a well-defined target protein, a single chain Fvantibody, in different transgenic crop species and cultured tissues. The effectof different regulatory elements and signals for subcellular targeting areconsidered. Practical considerations for the choice of a particular cropsystem,such as yield, storage, distribution and containment properties are discussed.

Cereals KDEL Molecular farming Pharmaceutical antibodies Plantibodies Recombinant proteins scFv Tobacco Transgenic crops