Journal of Applied Phycology

, Volume 14, Issue 2, pp 103–108

Symbiotic and dietary marine microalgae as a source of bioactive molecules–experience from natural products research

  • George G. Harrigan
  • Gilles Goetz
Article

DOI: 10.1023/A:1019570122349

Cite this article as:
Harrigan, G.G. & Goetz, G. Journal of Applied Phycology (2002) 14: 103. doi:10.1023/A:1019570122349

Abstract

Cyanobacterial metabolites have proven to be invaluable as tools in thedissection of signal transduction pathways in mammalian cells and some arecurrently under clinical evaluation as drug candidates. It is now also realizedthat cyanobacteria are the true biosynthetic origin of many bioactive moleculesisolated from marine invertebrates; marine invertebrates may sequestercyanobacteria through diet or by symbiosis. This review discusses thedietary-derived cyanobacterial origin of the dolastatins, potent cytotoxiccompounds, originally isolated from the Indian Ocean sea hare,Dolabella auricularia. A discussion on the dietarydissemination of cyanobacterial metabolites through the marine food chain isalso presented. Reference to the metabolites isolated fromDysidea sponges is given to illustrate their origin fromsymbiotic cyanobacteria associated with this organism.

Dietary-derived cyanobacteria Dolabella auricularia Dolastatins Dysidea species Symbiotic cyanobacteria 

Copyright information

© Kluwer Academic Publishers 2002

Authors and Affiliations

  • George G. Harrigan
    • 1
  • Gilles Goetz
    • 1
  1. 1.Pharmacia CorporationChesterfieldUSA

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