Pharmaceutical Research

, Volume 10, Issue 2, pp 187–196

Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women

  • Tanya L. Russell
  • Rosemary R. Berardi
  • Jeffrey L. Barnett
  • Lambros C. Dermentzoglou
  • Kathleen M. Jarvenpaa
  • Stephen P. Schmaltz
  • Jennifer B. Dressman
Article

DOI: 10.1023/A:1018970323716

Cite this article as:
Russell, T.L., Berardi, R.R., Barnett, J.L. et al. Pharm Res (1993) 10: 187. doi:10.1023/A:1018970323716

Abstract

Gastric and duodenal pH levels were measured in 79 healthy, elderly men and women (mean ± SD = 71 ± 5 years) under both fasted and fed conditions using the Heidelberg capsule technique. The pH was recorded for 1 hr in the fasted state, a standard liquid and solid meal of 1000 cal was given over 30 min, then the pH was measured for 4 hr postprandially. Results are given as medians and interquartile ranges: fasted gastric pH, 1.3 (1.1–1.6); gastric pH during the meal, 4.9 (3.9–5.5); fasted duodenal pH, 6.5 (6.2–6.7); and duodenal pH during the meal, 6.5 (6.4–6.7). Although fasted gastric pH, fasted duodenal pH, and duodenal pH during the meal differ statistically from those observed in young subjects, the differences are not expected to be clinically significant in terms of drug absorption for the majority of elderly subjects. Following a meal, gastric pH decreased from a peak pH of 6.2 (5.8–6.7) to pH 2.0 within 4 hr in most subjects. This rate of return was considerably slower than in young, healthy subjects. Nine subjects (11%) had a median fasted gastric pH >5.0, and in five of these subjects the median pH remained >5.0 postprandially. In this group, drugs and dosage forms which require an acidic environment for dissolution or release may be poorly assimilated.

gastric pHduodenal pHelderlygender effectsfood effectsfasted-state pHfed-state pHHeidelberg radiotelemetry capsule

Copyright information

© Plenum Publishing Corporation 1993

Authors and Affiliations

  • Tanya L. Russell
    • 1
  • Rosemary R. Berardi
    • 1
  • Jeffrey L. Barnett
    • 3
  • Lambros C. Dermentzoglou
    • 1
  • Kathleen M. Jarvenpaa
    • 5
  • Stephen P. Schmaltz
    • 5
  • Jennifer B. Dressman
    • 1
  1. 1.College of PharmacyThe University of MichiganAnn Arbor
  2. 2.Marion Merrell Dow Inc.Kansas City
  3. 3.School of MedicineThe University of Michigan HospitalAnn Arbor
  4. 4.Elpen S.A. Pharmaceutical IndustriesPikermiGreece
  5. 5.Clinical Research CenterThe University of Michigan HospitalAnn Arbor
  6. 6.JCAHONaperville