Pharmaceutical Research

, Volume 11, Issue 2, pp 272–277

The Controlled Release of Prednisolone Using Alginate Gel

  • Shinya Sugawara
  • Teruko Imai
  • Masaki Otagiri
Article

DOI: 10.1023/A:1018963626248

Cite this article as:
Sugawara, S., Imai, T. & Otagiri, M. Pharm Res (1994) 11: 272. doi:10.1023/A:1018963626248
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Abstract

In a release study of alginate gel beads, swelling and erosion of the beads were observed at pH 6.8, whereas no swelling occurred at pH 1.2. The amount of released prednisolone (PL) was greater at pH 6.8 than at pH 1.2. The lower the ratio of mannuronic acid block to guluronic acid block in alginate, the slower the release of PL. An increase in loaded PL in the beads resulted in a slower release of PL. The decrease in bead size caused a rapid release of PL. The addition of sodium alginate propylene glycol ester elevated the extent of PL release. The plasma profile of PL showed sustained-release behavior after the oral administration of the beads to beagles. Furthermore, the correlation between in vitro release and in vivo absorption of PL for various alginate gel beads was evaluated using deconvolution and convolution methods. The in vivo absorption of PL was correlated with the PL release at pH 1.2, and it differed from that at pH 6.8. The release of PL from alginate gel beads in vivo appeared to occur under conditions that cause little swelling.

alginate gel beads controlled release prednisolone in vitro/in vivo correlation beagle 

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Shinya Sugawara
    • 1
  • Teruko Imai
    • 1
  • Masaki Otagiri
    • 1
  1. 1.Faculty of Pharmaceutical SciencesKumamoto UniversityKumamotoJapan

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