Depression in Patients with Cirrhosis (Impact on Outcome)
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- Singh, N., Gayowski, T., Wagener, M.M. et al. Dig Dis Sci (1997) 42: 1421. doi:10.1023/A:1018898106656
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The impact of depression (assessed by the BeckDepression Inventory) on quality of life and outcome wasprospectively assessed in adult patients with cirrhosis.Patients with depression had significantly poorer perceived quality of life (P = 0.006),poorer adaptive coping (P = 0.001), and lower functionalstatus, ie, Karnofsky performance score (P = 0.06), ascompared to the nondepressed patients. Survival after transplantation was not different betweendepressed and nondepressed patients. However, thepatients with depression were significantly more likelyto die while awaiting transplantation than thenondepressed patients (P = 0.02). The difference inmortality between the depressed and the nondepressedpatients with end-stage liver disease could not beexplained by the severity of illness variables;Child-Pugh score, complications of liver disease, renal function,serum albumin, prothrombin time, frequency and durationof hospitalizations were not significantly different fordepressed and nondepressed patients. Symptoms of depression should be sought in patients withcirrhosis since depression is a modifiable illness thatis amenable to treatment.