Digestive Diseases and Sciences

, Volume 42, Issue 10, pp 2017–2023

HCV Infection in Egyptian Patients with Acute Hepatitis

  • Authors
  • Isabella Quinti
  • Diaa El Salman
  • Mohamed K. Monier
  • Barbara G. Hackbart
  • Magdi S. Darwish
  • Dina El-Zamiaty
  • Roberto Paganelli
  • F. Pandolfi
  • Ray R. Arthur
Article

DOI: 10.1023/A:1018897813268

Cite this article as:
Quinti, I., Salman, D.E., Monier, M.K. et al. Dig Dis Sci (1997) 42: 2017. doi:10.1023/A:1018897813268

Abstract

The diagnostics of community-acquired acute HCVhepatitis in an endemic area was studied in 110 Egyptianpatients with acute jaundice. In the first week of thejaundiced period 30 of 110 patients (27.3%) had anti-HCVantibodies. The majority already showed high levels ofanti-HCV IgG (25/30), associated with anti-HCV IgM innine of them. Five patients showed only an HCV IgMreactivity. Seven had also anti-HEV and/or anti-HBV: their jaundice couldthen be related to an acute infection caused by thoseviruses. All patients were infected with genotype 4a, inthree associated with the 3a. During the follow-up five patients seroconverted for IgG, whiletheir anti-HCV IgM did not show a uniform pattern ofreactivity. Patients with positive serology suspected ofan acute HCV infection were older than the patients with other acute hepatitis and showed a lowerpeak of ALT level. Seroconversion during acute hepatitisstrongly indicated HCV as the etiologic agent. However,the detection of anti-HCV IgG antibodies in the jaundiced period showed that the majorityof patients had already seroconverted to anti-HCVantibodies; in most of them it is possible tohypothesize a reactivation of a chronic HCVinfection.

HEPATITIS C VIRUSACUTE HEPATITISANTI-HCV ANTIBODIES

Copyright information

© Plenum Publishing Corporation 1997