Effect of Ethanol on Postprandial Duodenojejunal Motility in Humans
- Cite this article as:
- Schmidt, T., Eberle, R., Pfeiffer, A. et al. Dig Dis Sci (1997) 42: 1628. doi:10.1023/A:1018892827554
The effect of ethanol on postprandial smallbowel motility was investigated in eight healthyvolunteers using perfusion of nutrient solutions (17%proteins, 59% carbohydrates, 24% lipids) into thedescending duodenum (5 ml/min for 120 min). Anethanol-containing solution (4% w/v, 4.06 kcal/min, 1190mosmol/kg) was compared with the correspondingethanol-free solution (2.64 kcal/min, 160 mosmol/kg) andanother ethanol-free hyperosmolar solution adapted incaloric load and osmolality (4.06 kcal/min, 1160mosmol/kg). Motility was recorded with a data logger andsix pressure transducers at 3-cm intervals around the duodenojejunal flexure. Clusteredcontractions (27 ± 4/hr) migrating aborallythrough the whole recording segment were the predominantmotor pattern with ethanol compared with theethanol-free (10 ± 2/hr; P < 0.01) and the ethanol-free hyperosmolarsolution (6 ± 3/hr; P < 0.001). Other motilityparameters with ethanol were not different from theethanol-free solution, whereas the ethanol-freehyperosmolar solution showed a much less intense motor response. Weconclude that ethanol does modify human postprandialduodenojejunal motility by inducing propagative motorpatterns.