Digestive Diseases and Sciences

, Volume 43, Issue 1, pp 41–45

Serum Vascular Endothelial Growth Factor Levels in Various Liver Diseases

  • Authors
  • Fuyuhiko Akiyoshi
  • Michio Sata
  • Hiroshi Suzuki
  • Yasuyo Uchimura
  • Keiichi Mitsuyama
  • Katsuhiko Matsuo
  • Kyuichi Tanikawa
Article

DOI: 10.1023/A:1018863718430

Cite this article as:
Akiyoshi, F., Sata, M., Suzuki, H. et al. Dig Dis Sci (1998) 43: 41. doi:10.1023/A:1018863718430

Abstract

The clinical significance of circulatingvascular endothelial growth factor (VEGF) in patientswith various liver diseases was investigated. Twenty-onepatients with acute hepatitis (AH), 40 with chronic hepatitis (CH), 34 with cirrhosis (LC), 16 withfulminant hepatitis (FH), 10 with primary biliarycirrhosis (PBC), 12 with autoimmune hepatitis (AIH), and120 healthy individuals were included. Serum VEGF levels were measured by a chemiluminescenceenzyme-linked immunosorbent assay. The mean values ofserum VEGF levels in the patients with AH, CH, LC, FH,AIH, PBC, and control were 172.7, 58.0, 44.1, 37.3, 49.7, 74.9, and 65.0 pg/ml, respectively. Thepatients with AH had a level of serum VEGF significantlyhigher than that of the control group (P < 0.001).The serum VEGF levels in survivors of FH weresignificantly increased, but not in the nonsurvivors in therecovery phase compared with the levels on admission (P< 0.05). In the LC patients, serum VEGF levels weresignificantly lower than those of the control group (P < 0.05). These findings suggest thatserum VEGF level may be associated with hepatocyteregeneration grade.

VASCULAR ENDOTHELIAL GROWTH FACTORACUTE HEPATITISFULMINANT HEPATITISVARIOUS LIVER DISEASESHEPATOCYTE GROWTH FACTOR

Copyright information

© Plenum Publishing Corporation 1998