Digestive Diseases and Sciences

, Volume 42, Issue 12, pp 2505–2512

Common Pathogenetic Mechanisms in Symptomatic, Uncomplicated Gallstone Disease and Functional Dyspepsia (Volume Measurement of Gallbladder and Antrum Using Three-Dimensional Ultrasonography)

  • Trygve Hausken
  • Karl Sondenaa
  • Sven Svebak
  • Odd Helge Gilja
  • Snorri Olafsson
  • Svein Odegaard
  • Odd Soreide
  • Arnold Berstad
Article

DOI: 10.1023/A:1018860511702

Cite this article as:
Hausken, T., Sondenaa, K., Svebak, S. et al. Dig Dis Sci (1997) 42: 2505. doi:10.1023/A:1018860511702

Abstract

Following cholecystectomy for uncomplicatedgallstone disease (GS) some patients experiencepersistent symptoms suggesting an underlying functionaldisorder. To study this phenomenon, we have comparedsymptomatic GS with functional dyspepsia (FD) patients andhealthy individuals (C) with respect to putativepathogenetic mechanisms. Gallbladder and gastric antrumvolumes were estimated with three-dimensional (3D) ultrasonography before and 10 min afteringestion of 500 ml meat soup in 18 patients with GS.Volume estimation was performed digitally afterinteractive manual tracing and organ reconstruction inthree dimensions. Respiratory sinus arrhythmia (RSA)was calculated to index vagal tone. Abdominal symptomswere assessed by interview. The results were compared topreviously published data in patients with FD and C investigated with the exact samemethods. No significant differences were found betweengroups with respect to fasting gallbladder orgallbladder emptying. Antral volumes both fasting (P< 0.05) and postprandially (P < 0.01) were larger inGS and FD than in C. The soup meal induced dyspepticsymptoms in 2/18 (11% ) of C, 12/18 (67% ) of GS and15/17 (88%) of FD patients (P < 0.001). Compared with C, both GS and FD patients had significantlydecreased vagal tone (P < 0.001). There was nosignificant difference between GS and FD patients withrespect to antral volume, vagal tone, or symptoms. Weconcluded that both gallstone and functional dyspepsiapatients are characterized by dyspeptic symptoms inresponse to ingestion of 500 ml of meat soup, a widegastric antrum, low vagal tone, but normal gallbladder size and emptying. Thus, patients withsymptomatic, uncomplicated gallstone disease andfunctional dyspepsia seem to have common pathogeneticmechanisms.

GASTRIC ANTRUMGALLSTONEMOTILITYTHREE-DIMENSIONALULTRASONOGRAPHYVAGAL TONE

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Trygve Hausken
  • Karl Sondenaa
  • Sven Svebak
  • Odd Helge Gilja
  • Snorri Olafsson
  • Svein Odegaard
  • Odd Soreide
  • Arnold Berstad

There are no affiliations available