, Volume 43, Issue 6, pp 1241-1247

Treating Nonulcer Dyspepsia Considering Both Functional Disorders of the Digestive System and Psychiatric Conditions

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Abstract

Nonulcer dyspepsia (NUD) is a common syndrome,but the optimal treatments have yet to be established.This study was performed to determine the most effectivetreatment for NUD. Subjects were recruited through the Department of General InternalMedicine at the Kyushu University Hospital because oftheir somatic symptoms. When no organic lesions werefound, the patients were directed to consult ourdepartment (Psychosomatic Medicine); 194 consecutive NUDpatients were studied. All subjects were assessedpsychiatrically with the Structured Clinical Interviewfor DSM-III-R(SCID). Patients with serious NUD were hospitalized, and randomly divided into control(N = 42) and experimental groups (N = 86). The controlswere treated with physical treatment alone. Theexperimental group received psychiatric treatment inaddition, based on the results of SCID. The experimentalgroup showed a significant improvement compared with thecontrols (P < 0.0001). The treatment for NUD takinginto consideration both the physical and psychiatric conditions is highly effective.