Digestive Diseases and Sciences

, Volume 43, Issue 6, pp 1341–1346

Collagenous Colitis and Yersinia enterocolitica Infection

  • Authors
  • M. Makinen
  • S. Niemela
  • J. Lehtola
  • T. J. Karttunen

DOI: 10.1023/A:1018836614448

Cite this article as:
Makinen, M., Niemela, S., Lehtola, J. et al. Dig Dis Sci (1998) 43: 1341. doi:10.1023/A:1018836614448


Collagenous colitis is a rare clinical andpathological entity characterized by watery diarrhea anddeposition of collagen beneath the surface epithelium ofthe colon. Its etiology is unknown. We present a careful retrospective clinicopathologicalanalysis of six patients with collagenous colitisdiagnosed at our hospital during a three-year period.Three of the patients had had a Yersinia enterocolitica infection, detected by stool culture andelevated serum antibody titers, preceding the diagnosisof collagenous colitis. Four patients had duodenalvillous atrophy, which in two patients was refractory to a gluten-free diet. We propose that Yersiniaenterocolitica infection may be a triggering factor forthe development of collagenous colitis in some cases.Duodenal villous atrophy not responding to gluten withdrawal is common in association withcollagenous colitis.


Copyright information

© Plenum Publishing Corporation 1998