Digestive Diseases and Sciences

, Volume 42, Issue 7, pp 1383–1387

Helicobacter pylori Infection and Gastric Cancer (A Nested Case-Control Study in a Rural Area of Japan)

  • Authors
  • Yoshiyuki Watanabe
  • John H. Kurata
  • Shigeto Mizuno
  • Masako Mukai
  • Hideto Inokuchi
  • Kazumasa Miki
  • Kotaro Ozasa
  • Keiichi Kawai
Article

DOI: 10.1023/A:1018833819860

Cite this article as:
Watanabe, Y., Kurata, J.H., Mizuno, S. et al. Dig Dis Sci (1997) 42: 1383. doi:10.1023/A:1018833819860

Abstract

We conducted a seroepidemiological nested case-control study to determine the association of gastriccancer with Helicobacter pylori infection and atrophicgastritis. A cohort of 2858 participants in an annual multiphasic health check-up werefollowed for eight years. Data for 45 gastric cancercases and 225 sex-, age-, and address-matched controlsubjects were analyzed. Helicobacter pylori infectionwas determined by IgG antibodies, and atrophicgastritis was diagnosed by both serum pepsinogen I level(≤70 ng/ml) and the pepsinogen I/II ratio (≤3.0).Univariate analysis showed that Helicobacter pylori and atrophic gastritis were significantlyassociated with gastric cancer. In a multivariateanalysis, atrophic gastritis was associated withsignificantly increased risk of cancer (odds ratio,3.38; 95% confidence interval, 1.54-7.42); however,Helicobacter pylori was not associated with cancer (oddsratio, 1.84; 95% confidence interval, 0.59-5.72). Theseresults suggest that Helicobacter pylori infection alone is not directly associated with gastriccarcinogenesis but has an indirect relation to gastriccancer through the development of atrophicgastritis.

HELICOBACTER PYLORIGASTRIC CANCERATROPHIC GASTRITISEPIDEMIOLOGY

Copyright information

© Plenum Publishing Corporation 1997