, Volume 43, Issue 9, pp 2138-2142

Case Report: Primary Biliary Cirrhosis Associated with Cholangiocarcinoma

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Abstract

Primary biliary cirrhosis (PBC) is a chroniccholestatic liver disease of unknown etiology with anumber of immunological abnormalities. Althoughmalignant liver tumors associated with PBC wereconsidered rare in the past, recent studies havedemonstrated that the development of hepatocellularcarcinoma (HCC) in PBC is common, particularly inpatients with virus-related liver cirrhosis (1-7). Toour knowledge, the association of PBC with cholangiocarcinomahas not been previously reported.