Digestive Diseases and Sciences

, Volume 42, Issue 6, pp 1290–1294

Biliary Interleukin-6 and Tumor Necrosis Factor-α in Patients Undergoing Endoscopic Retrograde Cholangiopancreatography

  • Hugo R. Rosen
  • Peter J. Winkle
  • Bradley J. Kendall
  • David L. Diehl
Article

DOI: 10.1023/A:1018822628096

Cite this article as:
Rosen, H.R., Winkle, P.J., Kendall, B.J. et al. Dig Dis Sci (1997) 42: 1290. doi:10.1023/A:1018822628096

Abstract

Cytokines are low-molecular-weight proteinmediators that possess a wide spectrum of inflammatory,metabolic, and immunomodulatory properties. Cytokineshave been shown to be produced by monocytes/macrophages, lymphocytes, fibroblasts, endothelial cells,and more recently, hepatocytes and biliary epithelium.The aim of this study was to define biliary levels ofinterleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in patients undergoing endoscopicretrograde cholangiopancreatography (ERCP) in variousdisease states. Fifty-four patients undergoing ERCPcomprised the study group. IL-6 and TNF-α were measured in aspirated bile using an ELISAtechnique. Levels of both TNF-α and IL-6 weresignificantly higher in patients with cholangitis (P< 0.00001). Moreover, IL-6 was 100% specific forcholangitis since none of the patients without bacterialcholangitis — including patients with biliaryobstruction secondary to cholangiocarcinoma orpancreatic carcinoma — had measurable IL-6 intheir bile. Low levels of biliary TNF-α were detectable in fivepatients without cholangitis; the sensitivity andspecificity of TNF-α for cholangitis were 100% and82%, respectively. There was a strong statisticalcorrelation between biliary IL-6 and TNF-α levels (r= 0.819, P < 0.0001). In contrast, the correlationsbetween biliary cytokines and serum biochemicalparameters were weak. These results suggest that IL-6and TNF-α are sensitive markers for cholangitis and maydifferentiate it from other types of biliary tractdisease.

INTERLEUKIN-6 TUMOR NECROSIS FACTOR-α CHOLANGIOPANCREATOGRAPHY 

Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Hugo R. Rosen
  • Peter J. Winkle
  • Bradley J. Kendall
  • David L. Diehl

There are no affiliations available