Digestive Diseases and Sciences

, Volume 42, Issue 8, pp 1715–1723

Hepatotoxic Agent Thioacetamide Induces Biochemical and Histological Alterations in Rat Small Intestine

  • Maria Angeles Ortega
  • Maria Isabel Torres
  • Maria Isabel Fernandez
  • Antonio Rios
  • Antonio Sanchez-Pozo
  • Angel Gil
Article

DOI: 10.1023/A:1018817600238

Cite this article as:
Ortega, M.A., Torres, M.I., Fernandez, M.I. et al. Dig Dis Sci (1997) 42: 1715. doi:10.1023/A:1018817600238

Abstract

We have assessed the effect of the oral ingestion of thioacetamide on small intestine structure and function. Thioacetamide-treated rats showed diminished mucosa weight; protein, DNA, and RNA content; and leucine aminopeptidase activity as compared to controls in both jejunum and ileum. In the jejunum, there was a reduction in the activities of alkaline phosphatase, ATPase, glucose-6-phosphatase, and myeloperoxidase, whereas in the ileum, maltase, lactase, and γ-glutamyltranspeptidase were reduced. In both jejunum and ileum we found enlarged intercellular spaces, dark epithelial enterocytes, and lymphocyte infiltration. Enterocytes showed lobulated nuclei, deranged mitochondria with loss of their cristae, dilated rough endoplasmic reticulum containing dense material, and vesiculation of the smooth endoplasmic reticulum and the Golgi apparatus. Smooth muscle cells of the intestine exhibited ultrastructural alterations. These findings indicate that chronic oral intake of thioacetamide mimics not only hepatic alterations but also small intestine alterations normally associated with human cirrhosis.

THIOACETAMIDE SMALL INTESTINE CIRRHOSIS BRUSH-BORDER ENZYMES HISTOLOGY 
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Copyright information

© Plenum Publishing Corporation 1997

Authors and Affiliations

  • Maria Angeles Ortega
  • Maria Isabel Torres
  • Maria Isabel Fernandez
  • Antonio Rios
  • Antonio Sanchez-Pozo
  • Angel Gil

There are no affiliations available

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