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Inhibition of Gastric Secretion Relieves Diarrhea and Postprandial Urgency Associated with Irritable Bowel Syndrome or Functional Diarrhea

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Abstract

Five patients with gastroesophageal refluxdisease (GERD), who also had chronic functional diarrheaand postprandial urgency, unexpectedly noted rapidrelief of their diarrhea and urgency when they took lansoprazole for their heartburn. To determineif this surprising result was not fortuitous, all 20patients seen during the next six months for chronicdiarrhea and postprandial urgency due to irritable bowel syndrome (IBS) or functional diarrheawere treated with inhibitors of gastric secretion: 14with proton-pump inhibitors and 6 with H2blockers. All patients had rapid, marked improvement. Usually within three days, their symptomsabated and they usually had one to three formed stoolsper day. Relief continued during the one to six monthsthey were followed on therapy. Five patients stopped therapy, had recurrent diarrhea, and rapidrelief upon resuming therapy. Thus, inhibition ofgastric secretion effectively controls the diarrhea andpostprandial urgency associated with IBS or functional diarrhea, probably by diminishing thegastrocolic or gastroenteric reflex.

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Authors
  1. Bhavin Dave
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  2. Walter Rubin
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Dave, B., Rubin, W. Inhibition of Gastric Secretion Relieves Diarrhea and Postprandial Urgency Associated with Irritable Bowel Syndrome or Functional Diarrhea. Dig Dis Sci 44, 1893–1898 (1999). https://doi.org/10.1023/A:1018811226860

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