Distal Small Bowel Hormones (Correlation with Fasting Antroduodenal Motility and Gastric Emptying)
- Cite this article as:
- Naslund, E., Gryback, P., Backman, L. et al. Dig Dis Sci (1998) 43: 945. doi:10.1023/A:1018806129102
The aim of the present study was to study theinterdigestive motor complex (MMC), distal smallintestinal hormones, and gastric emptying innormal-weight and obese subjects before and afterjejunoileal bypass (JIB). Therefore, fasting antroduodenalmotility, gastric emptying, and RIA for motilin (MOT),neurotensin (NT), peptide YY (PYY), and glucagon-likepeptide-1 (GLP-1) was performed in nine obese subjects before (BMI 42 ± 4kg/m2) and nine months after (BMI 31 ±4) JIB, and in two groups of nine age- and sex-matchedcontrols (BMI 23 ± 1 and 21 ± 1). The rateof gastric emptying was faster in obese subjects and GLP-1 lower compared to normal-weightcontrols. After JIB, fewer phase III of the MMC wereobserved; fasting levels of PYY were elevated during theMMC; postprandial levels of NT, PYY, and GLP-1 were elevated; and gastric emptying was delayed. Ourresults suggest that there may be an association betweenan impaired GLP-1 response after food intake andobesity, and after JIB, PYY seems to regulateinterdigestive motility while GLP-1 may regulate early gastricemptying.