Efficacy of Electrical Stimulation at Frequencies Higher than Basal Rate in Canine Stomach
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- Familoni, B.O., Abell, T.L., Nemoto, D. et al. Dig Dis Sci (1997) 42: 892. doi:10.1023/A:1018804128695
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The optimum frequency for electricallystimulating motility in the stomach is still inquestion. Some studies of gastric electrical stimulation(GES) at near physiologic frequencies have reportedgastric electrical entrainment but with little efficacyin improving motility. In this study we examined theeffectiveness of electrical stimulation at a broad rangeof frequencies in entraining gastric electrical activity (GEA) and eliciting contractions in acanine model. The stomachs of six dogs, each implantedwith four pairs of stainless steel electrodes and twostrain gauges were stimulated at frequencies ranging from 3 to 30 cycles/min. GEA and contractionswere monitored before and during electrical stimulation.The ability of GES at different frequencies to reversethe effect of glucagon was also investigated. GEA was entrained in most animals atfrequencies close to the intrinsic rate as well as atfour to five times the intrinsic rate. At otherstimulation frequencies, the recorded electrical controlactivity either remained unchanged, uncoupled, or becamedysrhythmic. Contractile response to stimulation at fourto five times the intrinsic rate were significantlyhigher than those at frequencies close to the intrinsic rate (P 0.05). GES did not alter theeffect of glucagon. Stimulation at a frequency of fourtimes the basal rate of 5/min elicited the largestmotility index in dogs. Stimulation at frequencies much higher than the physiologic rate warrantsfurther study as a possible optimum range forGES.