Journal of Thrombosis and Thrombolysis

, Volume 9, Issue 3, pp 229–234

Moderate Alcohol Consumption is Associated with Decreased Platelet Activity in Patients Presenting with Acute Myocardial Infarction

  • Victor L. Serebruany
  • David R. Lowry
  • Sergei Y. Fuzailov
  • Douglas J. Levine
  • Christopher M. O'Connor
  • Paul A. Gurbel
Article

DOI: 10.1023/A:1018762510842

Cite this article as:
Serebruany, V.L., Lowry, D.R., Fuzailov, S.Y. et al. J Thromb Thrombolysis (2000) 9: 229. doi:10.1023/A:1018762510842

Abstract

Moderate alcohol consumption (MAC) and platelet inhibition have been independently associated with a reduced risk for the development of acute myocardial infarction (AMI). The effects of MAC on the initial platelet status in patients presenting with AMI are not elucidated. Here we sought to define the effects of MAC on platelet characteristics in AMI patients before applying any reperfusion strategies. The study was designed as an analysis within the cohort study in 23 patients with AMI enrolled in the GUSTO-III. Platelets were investigated by different techniques, including aggregometry, flow cytometry, and ELISA. MAC patients exhibited mild, but consistent, inhibition of platelet aggregability, surface receptor expression, and released substances as compared to non-alcohol consuming patients. These differences were significant for 5 µM ADP (p = 0.04), 10 µM ADP-induced aggregation (p = 0.02); P-selectin (p = 0.01), and PECAM-1 (p = 0.02) platelet-bound expression. Our study confirms that moderate alcohol consumption is associated with diminished platelet activation in patients presenting with AMI. The ability of MAC to favorably modulate the pre-reperfusion platelet status in such patients is of clinical importance, and further investigation in large-scale clinical trials seem warranted.

alcoholplateletsacute myocardial infarctionhuman

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Victor L. Serebruany
    • 1
  • David R. Lowry
    • 1
  • Sergei Y. Fuzailov
    • 1
  • Douglas J. Levine
    • 1
  • Christopher M. O'Connor
    • 2
  • Paul A. Gurbel
    • 1
  1. 1.Sinai Center for Thrombosis ResearchSchapiro Research BuildingBaltimore
  2. 2.Division of CardiologyDuke University Medical CenterDurham