Glycoconjugate Journal

, Volume 14, Issue 7, pp 795–799

Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides

  • Stephan Thurl
  • Jobst Henker
  • Manfred Siegel
  • Karlheinz Tovar
  • Gunther Sawatzki
Article

DOI: 10.1023/A:1018529703106

Cite this article as:
Thurl, S., Henker, J., Siegel, M. et al. Glycoconj J (1997) 14: 795. doi:10.1023/A:1018529703106

Abstract

Neutral oligosaccharides in human milk samples from approximately 50 women were analysed applying a recently developed high-pH anion-exchange chromatographic method. Three different oligosaccharide patterns could be detected in accordance with milk groups that had been already described. These oligosaccharide groups correspond to the Lewis blood types Le(a−b+), Le(a+b−) and Le(a−b−). In addition to these oligosaccharide patterns, a new carbohydrate pattern was detected in a milk sample from a Le(a−b−) individual. Here, only nonfucosylated oligosaccharides and compounds bearing a1,3 linked fucosyl residues were found, whereas structures with a1,2 and a1,4 fucosyl linkages were missing. This finding led to the hypothesis that there are four different oligosaccharide milk groups that fit well to the genetic basis of the Lewis blood group system.

human milk oligosaccharide pattern Lewis blood group 

Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • Stephan Thurl
    • 1
  • Jobst Henker
    • 2
  • Manfred Siegel
    • 3
  • Karlheinz Tovar
    • 1
  • Gunther Sawatzki
    • 1
  1. 1.Research DepartmentMilupa GmbH & Co. KGFriedrichsdorfGermany
  2. 2.Technische Universitat DresdenUniversitatsklinikum Carl Gustav CarusDresdenGermany
  3. 3.DRK Blutspendedienst SachsenInstitute of Transfusion MedicineDresdenGermany

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