Cancer Causes & Control

, Volume 8, Issue 2, pp 215–228

The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies


  • Geoffrey R. Howe
    • Division of EpidemiologyColumbia University School of Public Health
  • Kristan J. Aronson
    • Community Health and EpidemiologyQueens University
  • Enrique Benito
    • Unitat d'Epidemiologia i Registre de Cancer de Mallorca
  • Roberto Castelleto
    • Department of PathologyLa Plata National University
  • Jacqueline Cornée
    • INSERM
  • Stephen Duffy
    • Biostatistics UnitMedical Research Council
  • Richard P. Gallagher
    • Cancer Control Agency of British Columbia
  • José M. Iscovich
    • Ministry of Health JerusalemIsrael Center for Registration of Cancer and Allied Diseases
  • Jiao Deng-ao
    • Chejiang Medical University Hangcho
  • Rudolf Kaaks
    • International Agency for Research on Cancer
  • Gabriel A. Kune
    • Department of SurgeryUniversity of Melbourne
  • Susan Kune
    • Department of SurgeryUniversity of Melbourne
  • Hin P. Lee
    • Department of Community, Occupational and Family MedicineNational University of Singapore
  • Marion Lee
    • Department of Epidemiology and BiostatisticsUniversity of California
  • Anthony B. Miller
    • Department of Preventive Medicine and BiostatisticsUniversity of Toronto
  • Ruth K. Peters
    • Department of Preventive MedicineUniversity of Southern California, School of Medicine
  • John D. Potter
    • Division of Public Health SciencesFred Hutchinson Cancer Research Center
  • Elio Riboli
    • International Agency for Research on Cancer
  • Martha L. Slattery
    • Department of Oncological SciencesUniversity of Utah
  • Dimitrios Trichopoulos
    • Department of EpidemiologyHarvard School of Public Health
  • Albert Tuyns
    • International Agency for Research on Cancer
  • Anastasia Tzonou
    • Department of Hygiene and EpidemiologyUniversity of Athens
  • Lyndsey F. Watson
    • Department of SurgeryUniversity of Melbourne
  • Alice S. Whittemore
    • Department of Health Research and Policy, Division of EpidemiologyStanford University
  • Anna H. Wu-Williams
    • Department of Preventive MedicineUniversity of Southern California, School of Medicine
  • Zheng Shu
    • Chejiang Medical University Hangcho

DOI: 10.1023/A:1018476414781

Cite this article as:
Howe, G.R., Aronson, K.J., Benito, E. et al. Cancer Causes Control (1997) 8: 215. doi:10.1023/A:1018476414781


The objective of this study was to examine the effects of the intakeof dietary fat upon colorectal cancer risk in a combined analysis of datafrom 13 case-control studies previously conducted in populations withdiffering colorectal cancer rates and dietary practices. Original datarecords for 5,287 cases of colorectal cancer and 10,470 controls werecombined. Logistic regression analysis was used to estimate odds ratios (OR)for intakes of total energy, total fat and its components, and cholesterol.Positive associations with energy intake were observed for 11 of the 13studies. However, there was little, if any, evidence of anyenergy-independent effect of either total fat with ORs of 1.00, 0.95, 1.01,1.02, and 0.92 for quintiles of residuals of total fat intake (P trend =0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21, and 1.06 (Ptrend = 0.39). The analysis suggests that, among these case-control studies,there is no energy-independent association between dietary fat intake andrisk of colorectal cancer. It also suggests that simple substitution of fatby other sources of calories is unlikely to reduce meaningfully the risk ofcolorectal cancer.

Case-control studiescolorectal neoplasmsdietary fatenergy

Copyright information

© Chapman and Hall 1997