Quality of Life Research

, Volume 6, Issue 5, pp 385–392

Measurement of health-related quality of life in men with prostate cancer: the CaPSURE(tm) database


  • D P Lubeck
    • Technology Assessment Group
    • Division of Immunology, Department of MedicineStanford University
  • M S Litwin
    • Departments of Urology and Health ServicesUniversity of California
  • J M Henning
    • TAP Holdings Inc
  • P R Carroll
    • Department of UrologyUniversity of California

DOI: 10.1023/A:1018439528024

Cite this article as:
Lubeck, D.P., Litwin, M.S., Henning, J.M. et al. Qual Life Res (1997) 6: 385. doi:10.1023/A:1018439528024


This paper reviews the reliability and validity of an instrument for assessing health-related quality of life (HRQOL) in CaPSURE(tm) (Cancer of the Prostate Strategic Urologic Research Endeavor), an observational database of men with biopsy-confirmed prostate cancer. The questionnaire includes the RAND 36 item Health Survey 1.0, the UCLA Prostate Cancer Index and items measuring self-esteem and the impact of prostate cancer in general and on the family. The reliability and validity of this instrument are reported for a group of 2,382 men enrolled in CaPSURE(tm). Individuals complete HRQOL questionnaires at enrolment and quarterly thereafter. The subscales of the instrument resulted in a high internal-consistency reliability across all subscales (range=0.75-0.94). The test-retest reliability was good with the exception of the comparative health item (intraclass correlation coefficient (ICC)=0.55). The concurrent validity data included moderately strong associations with subscales of similar concepts and the ability to distinguish between patients who are known to be different - newly diagnosed (within 6 months) and patients diagnosed and treated an average of 3 years ago. Overall, this instrument demonstrated good reliability and validity and supported the need for incorporating HRQOL as a component of outcomes assessment in the management of patients with prostate cancer.

Prostate cancerquality of lifeobservational databases.
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© Chapman and Hall 1997