Quality of Life Research

, Volume 6, Issue 5, pp 385–392

Measurement of health-related quality of life in men with prostate cancer: the CaPSURE(tm) database

  • D P Lubeck
  • M S Litwin
  • J M Henning
  • P R Carroll

DOI: 10.1023/A:1018439528024

Cite this article as:
Lubeck, D.P., Litwin, M.S., Henning, J.M. et al. Qual Life Res (1997) 6: 385. doi:10.1023/A:1018439528024


This paper reviews the reliability and validity of an instrument for assessing health-related quality of life (HRQOL) in CaPSURE(tm) (Cancer of the Prostate Strategic Urologic Research Endeavor), an observational database of men with biopsy-confirmed prostate cancer. The questionnaire includes the RAND 36 item Health Survey 1.0, the UCLA Prostate Cancer Index and items measuring self-esteem and the impact of prostate cancer in general and on the family. The reliability and validity of this instrument are reported for a group of 2,382 men enrolled in CaPSURE(tm). Individuals complete HRQOL questionnaires at enrolment and quarterly thereafter. The subscales of the instrument resulted in a high internal-consistency reliability across all subscales (range=0.75-0.94). The test-retest reliability was good with the exception of the comparative health item (intraclass correlation coefficient (ICC)=0.55). The concurrent validity data included moderately strong associations with subscales of similar concepts and the ability to distinguish between patients who are known to be different - newly diagnosed (within 6 months) and patients diagnosed and treated an average of 3 years ago. Overall, this instrument demonstrated good reliability and validity and supported the need for incorporating HRQOL as a component of outcomes assessment in the management of patients with prostate cancer.

Prostate cancerquality of lifeobservational databases.

Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • D P Lubeck
    • 1
    • 2
  • M S Litwin
    • 3
  • J M Henning
    • 4
  • P R Carroll
    • 5
  1. 1.Technology Assessment GroupSan Francisco
  2. 2.Division of Immunology, Department of MedicineStanford UniversityStanfordUSA
  3. 3.Departments of Urology and Health ServicesUniversity of CaliforniaLos AngelesUSA
  4. 4.TAP Holdings IncDeerfieldUSA
  5. 5.Department of UrologyUniversity of CaliforniaSan FranciscoUSA